Present a human brain single-cell atlas spanning all developmental stages, highlighting temporal and cellular-specific expression of 3,380 neurological disorder risk genes.
Present findings on how prenatal valproic acid exposure disrupts neurodevelopment via RNF146-driven Wnt/β-catenin pathway dysregulation in an autism mouse model.
Presented the use of single-cell analysis workflows (public dataset integration, gene regulatory network construction, and DEG analysis) to investigate dendritic cell differentiation.
Published in Cancer Research, 2023
This study identifies Angiopoietin-2 (ANGPT2) as a key driver of immune evasion in melanoma by destabilizing vasculature. High ANGPT2 levels were linked to T-cell exclusion, while targeting ANGPT2 improved vascular integrity, T-cell infiltration, and immunotherapy effectiveness, highlighting its potential as a therapeutic target.
Published in Experimental & Molecular Medicine, 2023
This study investigates autism spectrum disorder (ASD) using a VPA-induced mouse model, uncovering that Rnf146 upregulation disrupts the Wnt/β-catenin pathway in the prefrontal cortex. This dysregulation impairs social behaviors, increases excitatory synaptic transmission, and alters synaptic organization, identifying Rnf146 as a potential therapeutic target.
Published in Experimental & Molecular Medicine, 2024
This study introduces a single-cell atlas of the developing human brain, spanning 393,060 cells from fetal stages to adulthood. It reveals the temporal and spatial dynamics of disorder risk genes, providing insights into brain development and its connection to neurological disorders, and serves as a valuable resource for neurodevelopmental research.
Published in Nature Communications, 2024
This study identifies five NSCLC subtypes through proteogenomic analysis, linking them to chromosome instability and tumor microenvironment variations for personalized treatment insights.
Published in Advanced Science, 2024
This study reveals that YTHDF proteins suppress cancer immunity by downregulating IFN-γ signaling, highlighting them as potential targets for enhancing immunotherapy in gastric cancer.