[BIOINFO 2024] Exploring Disorder Gene Dynamics with Single-cell Atlas of Human Brain Development
Invited Lecture at BIOINFO 2024 Annual Conference, Gyeongju, Korea
Curriculum Vitae
Education
- Master of Science, Integrated Biomedical and Life Sciences, Korea University
- March 2022 – August 2024
- Thesis: “Exploring Cellular and Temporal Specificity of Neurological Disorder Genes in Human Brain Development” (Advisor: Prof. Joon-Yong An)
- Bachelor of Science, Biosystem and Biomedical Sciences, Korea University
- March 2018 – February 2022
Publications (*co-first, +corresponding authors)
- Kim S*, Lee J*, Koh IG, Ji J, Kim HJ, Kim E, Park J, Park JE, An JY+, An integrative single-cell atlas to explore the cellular and temporal specificity of neurological disorder genes during human brain development. Exp Mol Med. 2024;56(10):2271-2282. DOI: 10.1038/s12276-024-01328-6.
- Park G*, Jang WE*, Kim S*, Gonzales EL, Ji J, Choi S, Kim U, Park JH, Mohammad HB, Bang G, Kang M, Kim S, Jeon SJ, Kim JY, Kim KP, Shin CY+, An JY+, Kim MS+, Lee YS+, Dysregulation of the Wnt/β-catenin signaling pathway via Rnf146 upregulation in a VPA-induced mouse model of autism spectrum disorder. Exp Mol Med. 2023;55(9):1783-1794. DOI: 10.1038/s12276-023-01065-2.
- Park HR*, Shiva A*, Cumming P, Kim S, Kim S, Kee E, Leong A, Chowdhury S, Shawber C, Carvajal R, Thurston G, An JY, Lund AW, Yang HW, Kim M+, Angiopoietin-2-dependent spatial vascular destabilization promotes T-cell exclusion and limits immunotherapy in melanoma. Cancer Res. 2023;83(12):1968-1983. DOI: 10.1158/0008-5472.CAN-22-2838.
- Song KJ*, Choi S, Kim K, Chang E, Park JS, Shim SB, Choi S, Heo YJ, An WJ, Yang DY, Cho KC, Ji W, Choi CM, Lee JC, Kim H, Yoo J, Ahn HS, Lee GH, Hwa C, Kim S, Kim K, Kim MS, Paek E, Jang SJ, Na S+, An JY+, Hwang HS+, Kim KP+, Proteogenomic Analysis Reveals Non-small Cell Lung Cancer Subtypes Predicting Chromosome Instability, and Tumor Microenvironment. at Commun. 2024;15(1):10164. DOI: 10.1038/s41467-024-54434-4.
- Jang D*, Hwa C, Kim S, Oh J, Shin S, Lee SJ, Kim J, Lee SE, Yang Y, Kim D, Lee S, Jung HR, Oh Y, Kim K, Lee HS, An JY+, Cho SY+, RNA N6-methyladenosine-binding protein YTHDFs redundantly attenuate cancer immunity by downregulating IFN-γ signaling in gastric cancer. Adv Sci (Weinh). DOI:10.1002/advs.202410806.
In Revision
- Kim JP*, Cho M*, Kim C*, Lee H, Jang B, Jung SH, Kim Y, Koh IG, Kim S, Shin D, Lee EH, Lee JY, Jang H, Kim B, Ham HG, Kim B, Kim Y, Cho AH, Raj T, Kim HK, Na D, Seo SW+, An JY+, Won HH+, Whole genome sequencing analyses suggest novel genetic factors associated with Alzheimer’s disease and an additive model for risk liability (In Revision, Nature communications)
- Kang M*, Choi J, Han J, Tiberai E, Kim S, Ryu HH, Kim S, Jang HB, Hwang KD, Lee J, Park O, Choi JE, Han DH, Kim J, Kim S, Kim Y, An JY, Kaang BK, Kim SJ, Neel BG, Park H, Kim CH+, Lee YS+, Aberrant BRAF signaling impairs learning and memory via reactive-like astrogliosis (In Revision, Journal of Clinical Investigation)
- Nam G*, Yeon HR, Park HB, Chang H, Cho BK, Jung H, Yi E, Kim S, An JY, Lee JE, Lee Y, Hwang EM, Ryu H, Chang J, Choi K, Choi EY+, CD99-mediated immunological synapse formation potentiates CAR-T cell function (In Revision, Nature communications)
Under Review
- Liu Y*, Young D, Zheng X, Desai I, Park J, Huynh N, Kuo C, Clarke GS, Luo JXJ, Moghadami S, Rajamani KT, Mu X, Chu J, Kim S, Parr S, Tan L, An JY, Paredes M, Wu Z, Sanders SJ, Jin X+, Conserved and dynamic ESR1 signaling in developing cortex mediates early postnatal social behavior (Under Review, Science)
- Kim S*, Kim H*, Porta Pelayo J*, Alvarez S*, Jang G, Kim J, Hoelscher VM, Calleja-Pérez B, Jung H, Yang Y, Lee HJ, Lee J, Kim S, Jiménez de la Peña M, Han AR, Lee DS, Ji S, Yu W, Kim HM, An JY, Oh WC, Kwon SK, Kim JY, Um JW, Fernández-Jaén A+, Ko J+, Bazedoxifene rescues sexually dimorphic autistic-like abnormalities in mice carrying a biallelic MDGA1 mutation (Under Review, Nature Medicine)
Honors & Awards
- Best Paper Award, BIOINFO 2024 Annual Conference, Korean Society for Bioinformatics
- AOHUPO Poster Award, HUPO 2023 World Congress, Human Protein Organization
- Outstanding Paper Award (1st Prize), 2023 L-HOPE Academic Paper Contest, BK21FOUR R&E Center for Learning Health Systems
- Excellent Poster Awards, ICKSMCB 2022 International Conference, Korean Society for Molecular and Cellular Biology
- Outstanding Poster Award, BIOINFO 2022 Annual Conference, Korean Society for Bioinformatics
- BK21FOUR Graduate Student Research Scholarship (08.2022 - 02.2024), BK21FOUR R&E Center for Learning Health Systems
- Scholarship for Bio-Scientists Career Exploration Program (2021), School of Biosystems and Biomedical Sciences, Korea University
Conference Presentations
Poster Presentations (Selected)
- KSBNS-APSN 2024: The 27th Annual Meeting of the Korean Society for Brain and Neural Sciences in conjunction with the 18th Biennial Meeting of the Asian-Pacific Society for Neurochemistry
- Poster: “An integrative single-cell atlas to explore the cellular and temporal specificity of neurological disorder genes during human brain development”
- Keystone Symposia - Single-Cell Biology: Tissue Genomics, Technologies and Disease 2024
- Poster: “Dysregulation of the Wnt/beta-catenin signaling pathway via Rnf146 upregulation in a VPA-induced mouse model of autism spectrum disorder”
- HUPO (Human Proteome Organization) 2023 World Congress
- Poster: “Dysregulation of the Wnt/beta-catenin signaling pathway via Rnf146 upregulation in a VPA-induced mouse model of autism spectrum disorder”
- The 19th KOGO (Korea Genome Organization) Winter Symposium 2023
- Poster: “Gene regulatory network reveals the landscape of myeloid dendritic cell differentiation”
- ICKSMCB 2022: International Conference of Korean Society for Molecular and Cellular Biology
- Poster: “Gene regulatory network reveals the landscape of myeloid dendritic cell differentiation”
Skills
- Bioinformatics Analysis Expertise
- Single-cell RNA-seq, Transcriptomics, Proteomics, Epigenomics
- Programming and Scripting Languages
- C, R, Python
- Operating Systems and Environments
- Unix/Linux