Seoyeon Kim

Seoyeon Kim

Graduate Student | she/her

Neuroscientist and Bioinformatician mapping the genetic landscapes that define the brain from development to neurological disorder.

Publications

You can also find my articles on my Google Scholar profile.

First Author Papers

An integrative single-cell atlas to explore the cellular and temporal specificity of neurological disorder genes during human brain development

Published in Experimental & Molecular Medicine, 2024

This study introduces a single-cell atlas of the developing human brain, spanning 393,060 cells from fetal stages to adulthood. It reveals the temporal and spatial dynamics of disorder risk genes, providing insights into brain development and its connection to neurological disorders, and serves as a valuable resource for neurodevelopmental research.

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Dysregulation of the Wnt-β-catenin signaling pathway via Rnf146 upregulation in a VPA-induced mouse model of autism spectrum disorder

Published in Experimental & Molecular Medicine, 2023

This study investigates autism spectrum disorder (ASD) using a VPA-induced mouse model, uncovering that Rnf146 upregulation disrupts the Wnt/β-catenin pathway in the prefrontal cortex. This dysregulation impairs social behaviors, increases excitatory synaptic transmission, and alters synaptic organization, identifying Rnf146 as a potential therapeutic target.

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Co-author Papers

Angiopoietin-2-Dependent Spatial Vascular Destabilization Promotes T-cell Exclusion and Limits Immunotherapy in Melanoma

Published in Cancer Research, 2023

This study identifies Angiopoietin-2 (ANGPT2) as a key driver of immune evasion in melanoma by destabilizing vasculature. High ANGPT2 levels were linked to T-cell exclusion, while targeting ANGPT2 improved vascular integrity, T-cell infiltration, and immunotherapy effectiveness, highlighting its potential as a therapeutic target.

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